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[RC] Arginine - Ridecamp Guest

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Authors M Burtscher, F Brunner, M Faulhaber, B Hotter, R Likar
Title   The prolonged intake of L-arginine-L-aspartate reduces blood lactate 
accumulation and oxygen consumption during submaximal exercise
Full source     Journal of Sports Science and Medicine, 2005, Vol 4, Iss 3, pp 
314-322

L-arginine-L-aspartate is widely used by athletes for its potentially ergogenic 
properties. However, only little information on its real efficacy is available 
from controlled studies. Therefore, we evaluated the effects of prolonged 
supplementation with L-arginine-L-aspartate on metabolic and cardiorespiratory 
responses to submaximal exercise in healthy athletes by a double blind 
placebo-controlled trial. Sixteen healthy male volunteers (22  3 years) 
performed incremental cycle spiroergometry up to 150 watts before and after 
intake of L-arginine-L-aspartate (3 grams per day) or placebo for a period of 3 
weeks. After intake of L-arginine-L-aspartate, blood lactate at 150 watts 
dropped from 2.8  0.8 to 2.0  0.9 mmol.l(-1) (p < 0.001) and total oxygen 
consumption during the 3-min period at 150 watts from 6.32  0.51 to 5.95  0.40 
l (p = 0.04) compared to placebo (2.7  1.1 to 2.7  1.4 mmol.l(-1); p = 0.9 and 
6.07  0.51 to 5.91  0.50 l; p = 0.3). Additionally, L-arginine-L-aspartate 
supplementation effected an increased fat utilisation at 50 watts. L-arginine 
and L-aspartate seem to have induced synergistic metabolic effects. L-arginine 
might have reduced lactic acid production by the inhibition of glycolysis and 
L-aspartate may have favoured fatty acid oxidation. Besides, the results 
indicate improved work efficiency after L-arginine-L-aspartate intake. The 
resulting increases of submaximal work capacity and exercise tolerance may have 
important implications for athletes as well as patients.


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