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Re: [RC] Selenium again - Susan Garlinghouse

Should it not be better to determine the glutathione peroxidase activity

and

calculate it on hemoglobin concentration basis? That's why we add Se after
all?



That is how it's done.   The assay doesn't actually measure selenium
directly, it measures GSH-Px activity and because of the association,
assumes a selenium deficiency or adequacy from that.



Studies however have proved, that also a big amount of Se is stored in

hair

and nails (human). By analysing Se levels in these samples it was

suggested

to "predict" the selenium history.
I tried to analyse Se in horse tail- and "fur" hair and "hoof" of a extra
supplied and not-supplied horses, but the horse, that got no extra

selenium

had higher levels in both "tissues".
Does anybody know, if Se is stored on the same way in horses as in humans?


Don't know the comparative correlation (humans being a fairly uninteresting
species in my book)<g>, but in horses, selenium is primarily stored in
muscle or liver tissue.  There is an incidental amount of selenium in hair,
but there is good research demonstrating that hair analysis is a *very* poor
diagnostic tool.  No reliable correlation between either hair content versus
whole body mineral status, let alone indicator of metabolically active forms
(ie, ionic calcium versus protein-bound); differences in results based on
location of the hair on the body (chest versus mane versus hindquarters) and
so on.

My favorite study collected hair samples from the same horse on the same day
at the same anatomical location and sent them under different names to the
same lab for analysis; and got back six different result reports and list of
"recommendations".  Cracked me up.

Susan G


Hugo

    |-----Original Message-----
    |From: ridecamp-owner@xxxxxxxxxxxxxxxxx
    |[mailto:ridecamp-owner@xxxxxxxxxxxxxxxxx]On Behalf Of Susan
    |Garlinghouse
    |Sent: vrijdag, 31 januari 2003 19:47
    |To: C. Eyler; Ridecamp
    |Subject: Re: [RC] Selenium again
    |
    |
    |
    |>Whole blood analysis is what my vet has done (at >Cornell,
    |except for the
    |time their equipment was on the >fritz and it went to Michigan).
    |
    |Yup, I stand corrected.  My copy of Diagnostic Techniques in
    |Equine Medicine
    |says whole (heparinized) blood, not serum.
    |
    |FWIW, it also says it takes about 5-6 weeks for changes in
    |selenium uptake
    |to be evident via blood tests.  I'm assuming that refers mostly to

oral

    |supplementation, prolly not so much via IM injections, but
    |don't know for
    |sure.
    |
    |Susan G
    |
    |
    |
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Ridecamp is a service of Endurance Net, http://www.endurance.net.
Information, Policy, Disclaimer: http://www.endurance.net/Ridecamp
Subscribe/Unsubscribe http://www.endurance.net/ridecamp/logon.asp

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