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    [RC] re: : [RC] Fungus Among Us - Michelle Fink


    Hi Stephanie -
    
    You might ask your vet about Fulvicin.  It's a feed through that you get by
    perscription, not super expensive, and as the hair grows out on your horse,
    it gets anti-fungal protection from the Fulvicin.  We used it along with
    bathing for a bad ringworm case on a horse.  See the stuff pasted below my
    sig line for a more complete description of griseofulvin (Fulvicin).
    
    Happy trails -
    Michelle
    (Colorado)
    
    from http://www.doctorfungus.org
    
    Griseofulvin
    
    Trade & Generic Names & General Features
    
    Griseofulvin is an antifungal agent first isolated from a Penicillium spp.
    in 1939. The compound is insoluble in water. It is effective after oral
    ingestion and reaches the skin and hair. It is deposited primarily in
    keratin precursor cells. Ingestion with a heavy meal and reduction in
    particle size enhances the absorption of griseofulvin [1193].
    
    Griseofulvin is currently produced by a number of different companies. It is
    available in two different forms. The microcrystalline form of griseofulvin
    is marketed as Fulvicin U/FT (Schering), Grifulvin VT (Ortho
    Dermatological), and GrisactinT (Wyeth-Ayerst). The trade names of
    ultramicrocrystalline form are Fulvicin P/GT (Schering), Gris-PEGT
    (Allergan), and Grisactin UltraT (Wyeth-Ayerst).
    
    
    Mechanism(s) of Action
    
    Griseofulvin inhibits fungal mitosis by disrupting the mitotic spindle
    through interaction with polymerized microtubules [827].
    
    
    Susceptibility Patterns
    
    Griseofulvin is mainly effective on a specific group of fungi,
    dermatophytes. However, a standardized in vitro susceptibility testing
    methodology is not yet available for this group of fungi. Studies to address
    this to question are in progress. One of the parameters under investigation
    is the standard medium to be used in the test [990]. This medium should
    enhance conidium formation in dermatophytes.
    
    Although as yet unstandardized, the in vitro activity of griseofulvin has
    been tested against various dermatophytes. The major goal of performing
    susceptibility tests for griseofulvin is to compare its in vitro activity
    with those of novel agents used in treatment of dermatophytosis.
    Griseofulvin yields higher MICs compared to terbinafine and itraconazole
    when tested against Trichophyton rubrum isolates [990, 1092]. It is also
    less active than voriconazole against most dermatophytes [2160]. The reduced
    in vitro activity of griseofulvin against Trichophyton mentagrophytes
    compared to Trichophyton rubrum is also noteworthy [1092]. However, the
    meaning and clinical significance of these data demand further
    investigations and development of a standard in vitro susceptibility testing
    method.
    
    For griseofulvin MICs obtained for various types of fungi, see
    susceptibility patterns and the susceptibility database.
    
    
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