Ridecamp: Re: [RC] malox

I was speculating that it was probably the magnesium hydroxide in the
Maalox--my guess was that it was too much in conjunction with the magnesium
in electrolyte solutions...so I went to the KER website to see if their work
on it was there.  According to their study, when they were creating NeighLox
(their equine antacid) they started out mimicking human antacids like
Maalox, but at high doses they became ataxic and also acted like they were
tying up.  They discovered that the problem was the magnesium hydroxide.

Turns out I was on the right track, but for the wrong reason.  (I hate it
when that happens!)  Now I think the reason for the sensitivity to the
magnesium hydroxide not so much the concentration as it is the speed with
which it is absorbed--the same amount of magnesium supplied by something
like magnesium oxide probably would have no adverse effects because it is
absorbed more slowly.  Hydroxide is a strong base (I see I remember
SOMETHING from Chem. 101), and would react immediately with stomach acid
when it comes in contact with it.  Not a bad thing as far as solving the
acid indigestion, but by doing so it would immediately release a flood of
magnesium.  It would be like giving them a bolus injection of magnesium too
rapidly.

Here's a link to the KER study, if anyone is interested in reading it:

http://www.neigh-lox.com/ulcerbook.pdf


  ---- Original Message -----
From: "John & Sue Greenall" <greenall@xxxxxxxxxxxxx>
To: <ridecamp@xxxxxxxxxxxxx>
Sent: Wednesday, June 05, 2002 1:11 PM
Subject: [RC] malox


> I believe that Kentucky Research said that Malox was not a good
> mixture with electrolytes for some reason.  Anyone know what that
> is?  I am now being told to give Malox with electrolytes to help
> prevent ulcers.  Will this ever end??
> John and Sue Greenall
> mailto:greenall@xxxxxxxxxxxxx
> http://www.vermontel.com/~greenall
>
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 Ridecamp is a service of Endurance Net, http://www.endurance.net.
 Information, Policy, Disclaimer: http://www.endurance.net/Ridecamp
=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=